Table 3. All-cause, heart-related, and bladder-related mortality of patients by demographic and clinical characteristics at diagnosis.
| Group | All causes | Heart-specific disease | BCa | |||||
|---|---|---|---|---|---|---|---|---|
| HR | P value | SHR | P value | SHR | P value | |||
| Marital | ||||||||
| Married | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | |||||
| Widowed/divorced | 1.26 (1.22, 1.30) | <0.001 | 1.16 (1.05, 1.28) | 0.004 | 1.18 (1.13, 1.23) | <0.001 | ||
| Single | 1.27 (1.22, 1.33) | <0.001 | 1.14 (0.97, 1.34) | 0.104 | 1.16 (1.10, 1.23) | <0.001 | ||
| Unknown | 1.11 (1.03, 1.20) | 0.006 | 0.95 (0.75, 1.21) | 0.691 | 1.14 (1.03, 1.25) | 0.01 | ||
| Age | ||||||||
| <50 | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | |||||
| 50–64 | 1.24 (1.15, 1.33) | <0.001 | 2.32 (1.50, 3.60) | <0.001 | 1.08 (1.00, 1.17) | 0.056 | ||
| 65–74 | 1.63 (1.52, 1.75) | <0.001 | 5.40 (3.52, 8.27) | <0.001 | 1.16 (1.07, 1.26) | <0.001 | ||
| ≥75 | 2.45 (2.28, 2.63) | <0.001 | 10.72 (7.01, 16.38) | <0.001 | 1.39 (1.28, 1.50) | <0.001 | ||
| Year of diagnosis | ||||||||
| 2000–2005 | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | |||||
| 2006–2012 | 0.87 (0.84, 0.90) | <0.001 | 0.59 (0.54, 0.65) | <0.001 | 0.83 (0.80, 0.86) | <0.001 | ||
| Race | ||||||||
| White | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | |||||
| Black | 1.14 (1.08, 1.20) | <0.001 | 0.92 (0.76, 1.12) | 0.424 | 1.16 (1.09, 1.24) | <0.001 | ||
| Other | 0.83 (0.78, 0.89) | <0.001 | 0.65 (0.51, 0.83) | 0.001 | 0.87 (0.80, 0.95) | 0.002 | ||
| Unknown | 0.27 (0.16, 0.46) | <0.001 | 0.36 (0.09, 1.43) | 0.146 | 0.40 (0.23, 0.68) | 0.001 | ||
| Grading | ||||||||
| I | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | |||||
| II | 1.23 (1.10, 1.37) | <0.001 | 1.24 (0.98, 1.57) | 0.071 | 1.22 (1.02, 1.45) | 0.027 | ||
| III | 1.52 (1.38, 1.69) | <0.001 | 1.13 (0.90, 1.43) | 0.298 | 1.73 (1.47, 2.03) | <0.001 | ||
| IV | 1.40 (1.27, 1.55) | <0.001 | 1.06 (0.84, 1.34) | 0.644 | 1.65 (1.41, 1.94) | <0.001 | ||
| Unknown | 1.49 (1.34, 1.66) | <0.001 | 1.15 (0.90, 1.48) | 0.266 | 1.53 (1.29, 1.81) | <0.001 | ||
| Stage | ||||||||
| In situ | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | |||||
| Local | 2.86 (2.68, 3.05) | <0.001 | 1.02 (0.89, 1.18) | 0.749 | 10.57 (9.10, 12.29) | <0.001 | ||
| Regional | 6.12 (5.70, 6.56) | <0.001 | 0.77 (0.64, 0.93) | 0.005 | 24.89 (21.34, 29.03) | <0.001 | ||
| Distant | 14.30 (13.34, 15.32) | <0.001 | 0.37 (0.29, 0.47) | <0.001 | 48.79 (41.91, 56.79) | <0.001 | ||
| Unknown | 4.55 (3.99, 5.18) | <0.001 | 0.63 (0.40, 0.99) | 0.047 | 18.47 (15.06, 22.65) | <0.001 | ||
| Treatment | ||||||||
| RC | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | |||||
| RT/RT + CT | 1.93 (1.85, 2.00) | <0.001 | 1.38 (1.22, 1.57) | <0.001 | 1.68 (1.60, 1.77) | <0.001 | ||
| CT | 1.21 (1.16, 1.26) | <0.001 | 1.18 (1.04, 1.35) | 0.013 | 1.17 (1.11, 1.22) | <0.001 | ||
BCa, bladder cancer; HR, hazard ratio; SHR, sub-distribution hazard ratio; RC, radical cystectomy; RT, radiotherapy; CT, chemotherapy.