Table 4. All-cause, heart-related, and bladder-related mortality in patients with BCa who underwent RC, RT/RT + CT, or CT at diagnosis, analyzed by age and treatment subgroup.
| Age | Variables | All causes | Heart-specific disease | BCa | |||||
|---|---|---|---|---|---|---|---|---|---|
| HR | P value | SHR | P value | SHR | P value | ||||
| <50 | Treatment | ||||||||
| RC | |||||||||
| RT/RT + CT | 2.15 (1.78, 2.60) | <0.001 | 1.62 (0.52, 5.12) | 0.407 | 1.89 (1.50, 2.39) | <0.001 | |||
| CT | 1.39 (1.18, 1.64) | <0.001 | 1.26 (0.52, 3.09) | 0.609 | 1.34 (1.12, 1.61) | 0.002 | |||
| 50–64 | Treatment | ||||||||
| RC | |||||||||
| RT/RT + CT | 1.84 (1.69, 2.00) | <0.001 | 1.29 (0.83, 2.00) | 0.261 | 1.67 (1.51, 1.86) | <0.001 | |||
| CT | 1.27 (1.18, 1.37) | <0.001 | 1.00 (0.69, 1.46) | 0.981 | 1.26 (1.16, 1.38) | <0.001 | |||
| 65–74 | Treatment | ||||||||
| RC | |||||||||
| RT/RT + CT | 1.90 (1.76, 2.05) | <0.001 | 1.59 (1.25, 2.02) | <0.001 | 1.57 (1.43, 1.73) | <0.001 | |||
| CT | 1.17 (1.09, 1.26) | <0.001 | 1.00 (0.79, 1.27) | 0.995 | 1.20 (1.09, 1.31) | <0.001 | |||
| ≥75 | Treatment | ||||||||
| RC | |||||||||
| RT/RT + CT | 1.98 (1.86, 2.10) | <0.001 | 1.49 (1.25, 1.77) | <0.001 | 1.62 (1.50, 1.75) | <0.001 | |||
| CT | 1.17 (1.10, 1.26) | <0.001 | 1.38 (1.15, 1.66) | 0.001 | 1.01 (0.93, 1.11) | 0.754 | |||
BCa, bladder cancer; RC, radical cystectomy; RT, radiotherapy; CT, chemotherapy; HR, hazard ratio; SHR, sub-distribution hazard ratio.