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. 2021 Nov 8;8:35. doi: 10.1186/s40580-021-00285-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Simulation of kidney organoid-on-a-chip under various fluidic flows and geometric conditions. A Simulated streamline profile across the microchannel and cross-sectional velocity profiles around the kidney organoid (bottom). B Shear stress acting on the kidney organoid surface with respect to the microwell diameter. C Shear stress acting on the kidney organoid surface with respect to the microwell height. D Simulated cross-sectional streamline across the microchannel (1 mm well height, 1.5 mm well diameter). E Wall shear stress acting on the kidney organoid surface