Table 2.
All measured and derived LV and coronary hemodynamic indices and pressure-volume derived indices in participants at baseline and following ISDN
| Baseline | ISDN | |
|---|---|---|
| LV hemodynamic measurements | ||
| Heart Rate (bpm) | 61±10 | 65±12* |
| End-diastolic pressure (mmHg) | 13.1±6.5 | 8.3±6.4* |
| End-systolic Pressure (mmHg) | 122.7±18.0 | 96.0±19.0* |
| EDV (mL) | 112.1±32.7 | 102.7±29.5* |
| ESV (mL) | 44.3±15.3 | 36.1±15.6* |
| Stroke work (mmHg.mL) | 7243±2637 | 6348±2670* |
| dP/dT (min mmHg/s) | −1284±179 | −906±355* |
| Tau (ms) | 34.1±4.6 | 32.5±4.3* |
| dP/dTmax (mmHg/s) | 1247±206 | 1227±195 |
| SBP (mmHg) | 133±23 | 108±18* |
| DBP (mmHg) | 99±10 | 90 ±10* |
| Beta EDPVR (SB) | 6.0±0.3 | 5.8±0.2* |
| PVA Joules | 1.49±0.56 | 1.15±0.4* |
| SW:PVA | 65.2±6.3 | 73.8±9.0* |
| Ees (SP) (mmHg/mL) | 2.2±1.0 | 2.4±1.2 |
| Ea (mmHg/mL) | 1.6±0.6 | 1.3±0.5* |
| Ea:Ees(SP) | 0.8±0.2 | 0.6±0.2* |
| Coronary hemodynamics and wave energies | ||
| Coronary flow velocity (cm/s) | 17.7 | 20.7 |
| Distal coronary pressure (mmHg) | 87.2 | 76.2* |
| Microvascular resistance (mmHg/cm/s) | 7.4 | 5.4* |
| Stenosis resistance (mmHg/cm/s) | 3.9 | 2.4* |
| Diastolic time fraction | 0.64 | 0.68* |
| Forward compression wave (J/m2/sec2) | 5822 | 4568 |
| Forward expansion wave (J/m2/sec2) | 3649 | 2852 |
| Backward compression wave (J/m2/sec2) | −7214 | −5843 |
| Backward expansion wave (J/m2/sec2) | −6476 | −5882 |
Patients served as their own control at baseline. Data are displayed as mean ± SD. * Indicates P value<0.05. HR heart rate, EDV end-diastolic volume, ESV end-systolic volume, EF ejection fraction, EDP end-diastolic pressure, ESP end-systolic pressure, Ees end-systolic elastance, Ea arterial elastance, SW stroke work, PVA pressure-volume area, β EDPVR (SB) single beat estimate of the beta coefficient of the end-diastolic pressure-volume relationship curve, U mean coronary blood flow velocity, Pd mean distal coronary pressure, DTF diastolic time fraction, MVR microvascular resistance, SR stenosis resistance, BEW backward expansion wave, FEW forward expansion wave