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. 2021 Nov 8;11:21786. doi: 10.1038/s41598-021-01129-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Figure 6. — Pathway-based data integration and visualization of KEGG PATHWAY 00270 “Cysteine and methionine metabolism”. Analysis was conducted in R³¹ using the R package pathview⁴², which renders the metabolome and transcriptome data on the pathway. The color of genes and compounds means log₂ fold change (log₂FC), separated by three parts containing the ratio of A1G vs. GC (left), MG vs. A1G (middle), and MG vs. GC (right). Control mice on Earth (GC), mice under artificial earth-gravity in space (A1G), and mice under microgravity in space (MG). Images were obtained by KEGG^43,44.