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. 2021 Nov 8;11:21869. doi: 10.1038/s41598-021-01248-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Stacked bar plots of relative changes in gut microbiota composition of FRL rats. Each bar represents all the OTUs observed across samples from one rat. OTUs in blue were detected in both pre-and post-FMT samples, while OTUs in purple were novel in the rat and not detected in the donor material. The green OTUs were common in both rats and humans, while the red percentage was unique to the human donor material only. FMT-MDD: Faecal microbiota transplantation from patients with MDD into rats. FMT-Healthy: Faecal microbiota transplantation from healthy individuals into rats. FMT-MDD-Ser: Faecal microbiota transplantation from patients with MDD into rats combined with treatment with sertraline.