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. 2021 Nov 8;7:342. doi: 10.1038/s41420-021-00742-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A DNA fragmentation induced by APAP in mouse livers was detected by TUNEL assay at different tine point after APAP treatment. Scale: 100 μm. B The serum IL-6 concentration of mice in the two groups at 8 h after APAP treatment was measured by ELISA; C Q-PCR was used to detect mRNA levels of cytokines in the liver of WT and CD5L^−/− mice at 8 h after APAP treatment (n = 4 for each genotype at each time point). The results are presented as means ± SD of at least three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001.