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. 2021 Nov 8;11:21601. doi: 10.1038/s41598-021-00844-z

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SPR binding shift for undiluted serum (A) and serum at a 1:20 dilution (B) from SARS-CoV-2-positive individuals at weeks 4 (W4) and 16 (W16) post-diagnosis for the native (black, n = 16, 4 age groups) and B.1.351 (white, n = 4, 18–49 years) spike proteins, and for vaccinated individuals (gray, n = 5) for the native spike protein. (C) A dissociation constant was estimated from the dilution series assuming a 1:1 binding model according to the data presented in panels (A) and (B). The dilution series used in SPR data acquisition consisted of the following: 1:40, 1:20, 1:10, 1:5, 1:2.5 and undiluted serum. In all panels, error bars represent one standard deviation.