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. 2021 Sep 29;125(10):1365–1376. doi: 10.1038/s41416-021-01547-y

Fig. 5. Overall survival analysis according to CDK4 and CDK6 expression in two cohorts of patients with MPM.

Fig. 5

Kaplan–Meier plots of overall survival (OS) in MPM patients according to a CDK4 and b CDK6 gene expression levels based on data obtained from Bueno et al. (left column) and Hmeljak et al. (middle column) cohorts or the combination of both (right column). High levels of CDK4 or CDK6 (red line) were significantly associated with poor OS in patients with MPM. In each cohort, the high and low expression levels were defined based upon the median. P values and hazard ratios (HRs) were calculated by likelihood ratio test and multivariate Cox regression analysis, respectively.