Table 6.

The validated candidate drugs by CMAP analysis.

Drug name	Gene names (↓:Downregulated and ↑: upregulated)
SIROLIMUS	TYMS (↑), NLE1 (↑), CDC25A (↑), BYSL (↓), UTP3 (↓), GNL3 (↓), MRTO4 (↓), UTP6 (↓), KRR1 (↓), CDC25A (↓)
METHYLDOPA	NMD3 (↓)
VORINOSTAT	CCNB2 (↓)
PACLITAXEL	KHDRBS1 (↑)
DAUNORUBICIN	BUB1B (↓), CENPE (↓), NMD3 (↓)
METHOTREXATE	UBE2C (↓), CDC20 (↓), BUB1B (↓), KIF20A (↓), PTTG1 (↓), CDKN3 (↓), KIF11 (↓), TACC3 (↓), TOP2A (↓), TTK (↓), CENPF (↓), CCNB2 (↓)
NICLOSAMIDE	HNRNPA1 (↑) GINS2 (↓), BYSL (↓), RRM2 (↓)
ETOPOSIDE	UBE2C (↓), CDC20 (↓), KIF20A (↓), NCAPG (↓), PTTG1 (↓), PNO1 (↓), NEK2 (↓), CENPF (↓), TOP2A (↓), KIF11 (↓), CDKN3 (↓), TACC3 (↓), TTK (↓)