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. 2021 Nov 8;11:21849. doi: 10.1038/s41598-021-01363-7

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© Crown 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Humoral immune response with SmT1-based vaccine formulations in hamsters. Syrian Golden hamsters (n = 6/group) were immunized i.m. with 3 µg of SmT1 alone or with SLA, CpG or SLA + CpG on Days 0 ± 21. Serum was collected on Days 21 (A) and 34 (B) and analyzed by ELISA to determine the antibody titers. Grouped data is presented as geometric mean + 95% confidence interval. Serum from Day 34 was also analyzed at a final serum dilution of 1:25 (C) and 1:75 (D) by cell-based surrogate neutralization assay. Grouped data is presented as mean + standard error of mean. Statistical significance of differences for the adjuvanted groups vs. the antigen alone control group is shown: **p < 0.01, ***p < 0.001 and ****p < 0.0001 by one-way ANOVA followed by Tukey's multiple comparisons test.