Table 1.
Demographic and clinical characteristics of the three study groups
| Characteristic | No. or median (% or interquartile range) | |||
|---|---|---|---|---|
| gFTLD-TDP (n=15) | AD-TDP (n=10) | Pure-TDP (n=10) | p-value | |
| Female | 6 (40%) | 5 (50%) | 4 (40%) | 0.91 |
| White/Caucasian | 14 (93%) | 10 (100%) | 10 (100%) | >0.99 |
| Age at onset, years | 68 (66 – 70) | 69 (67 – 75) | 73 (67 – 77) | 0.20 |
| Disease duration, years | 10 (9 – 15) | 11 (10 – 18) | 9 (5 – 14) | 0.27 |
| Age at death, years | 79 (76 – 84) | 83 (78 – 87) | 78 (77 – 87) | 0.24 |
| Family history | 10 (67%) | 8 (80%) | 4 (40%) | 0.18 |
| Education, years | 15 (12 – 16) | 16 (12 – 17) | 16 (14 – 17) | 0.67 |
| Last MMSE/30 | 13 (5 – 25) | 17 (5 – 22) | 16 (2 – 22) | 0.85a |
| Clinical diagnosis | ||||
| FTLD clinical spectrum diagnosis | 5 (33%) | 3 (30%) | 3 (30%) | |
| Frontotemporal dementia (FTD) | 2 (13%) | 0 (0%) | 0 (0%) | 0.75 |
| FTD-Motor Neuron Disease | 0 (0%) | 0 (0%) | 1 (10%) | |
| Primary progressive aphasia | 2 (13%) | 1 (10%) | 1 (10%) | |
| Progressive supranuclear palsy | 1 (7%) | 0 (0%) | 1 (10%) | |
| Corticobasal syndrome | 0 (0%) | 2 (20%) | 0 (0%) | |
| Alzheimer’s dementia | 8 (53%) | 7 (70%) | 5 (50%) | |
| Dementia with Lewy bodies | 1 (7%) | 0 (0%) | 1 (10%) | |
| Vascular dementiab | 1 (7%) | 0 (0%) | 1 (10%) | |
Data are represented as median (interquartile range) for continuous variables or number (per cent) for categorical variables. P-values are from Kruskal-Wallis test for continuous variables or Fisher’s exact test for categorical variables
a
Adjusted for disease duration at the time of last MMSE
b
No or minimal evidence (vascular score 0/1) of cerebrovascular disease on brain autopsy in both cases