Figure 3.

Simplified schematic representation summarizing the causal relationships by which miRNA dysregulation can lead to accumulation of heightened DNA damage. The figure includes only those forms of DNA damage, DDR and DNA repair pathways whose induction/perpetuation have been causally linked with at least one dysregulated miRNA expression (Mismatch Repair, Non-Homologous End Joining, Homologous Recombination and Interstrand Crosslink Repair). “(?)” denotes that so far no information is available for the miRNA modulation of the particular DNA damage pathway.