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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Semin Cancer Biol. 2021 May 9;76:120–131. doi: 10.1016/j.semcancer.2021.05.004

Figure 4.

Figure 4.

Simplified schematic representation summarizing the causal relationships by which miRNA dysregulation leads to mitotic disruption. The figure depicts how miRNA(s) disrupt prometaphase to metaphase transition and cause dysregulation of Spindle Assembly Checkpoint by targeting components of the Mitotic Checkpoint Complex leading to improper chromatid segregation and ultimately aneuploidy. Please note that no data are currently available causally linking miRNA dysregulation to disruption of other cell cycle stages.