Table 1:
miRNA | TargetGene | Binding Sequence on Target | Reference |
---|---|---|---|
miR-210 | E2F3 | 5' …UGUCUAAACGCACA… 3' | [60] |
miR-148a-3p | CD274(PD-L1) | 5' …GCACUG… 3' | [96] |
miR-129-5p | SOX4 | 5' …GCAAAA… 3' | [98] |
miR-129-3p | SOX4 | 5' …AAGGGCU… 3' | [98] |
miR-21 | MSH2 | 5' …AUAAGCUA… 3' | [99] |
miR-155 | MLH1 | Not Described | [97] |
miR-155 | MSH2 | Not Described | [97] |
miR-155 | MSH6 | Not Described | [97] |
miR-497 | SSRP1 | 5' …ACUCUGCUGCU… 3' | [71] |
miR-497 | SSRP1 | 5' …AGGAUGUAG-CUGCUGCU… 3' | [71] |
miR-146a-5p | MALAT1 | 5' …AGUUCUC… 3' | [128] |
miR-216b-5p | MALAT1 | 5' …TAGAGAU… 3' | [128] |
miR-22 | MDC1 | 5' …UGUCAUAAGUGGCAGCU… 3' | [140] |
miR-222 | RAD51 | Not Described | [141] |
miR-205 | RAD17 | 5' …GAUGUGAAGG… 3' | [132] |
miR-205 | BRCA1 | 5' … GACUUCUG-GCUAUGCAAGG… 3' | [132] |
miR-128-3p | SPTAN1 | 5'…AUCAUGUCACUGUGG…3' | [122] |
miR-138 | H2AX | 5'… CAAGCACCUAGAUACCAGC… 3' | [126] |
miR-214 | RNF8 | 5'…CAACCUGCUG…3' | [129] |
miR-223-3p | PARP-1 | 5'…GGUAGAU..A..AAACUGAC.. | [75] |
miR-223-3p | CTIP | 5'…CCG..A.AAGUAAAACGUGAGA..3' | [75] |
miR-223-3p | PSO4 | 5'…AUGACCAGCUUAAAACUAGCU..3' | [75] |
miR-26a | CHFR | 5' …UCUGGAAUAAUACUUGAA… 3' | [58] |
miR-509-3-5p | PLK1 | 5' …GUGCCAUGUCUGCAGUG… 3' | [160] |
miR-193a-3p | RASSF1 | 5' …GUGUGAGUGUGACAGGGCCAGUGG… 3' | [161] |
let-7b | Aurora B | 5' … UCCCUUAUCUGUUUUCUACCUCC… 3' | [62] |
miR-155 | BUB1 | 5' …CCCTTGTT.CCCTTAGCATTA… 3' | [77] |
miR-125b | MAD 1 | 5' …UGCAUCAAUCGGACUCGGGGGC… 3' | [163] |
miR-493-3p | MAD 2 | 5' …CCUUUUGACCUUCAU… 3' | [63] |
miR-28-5p | MAD 2 | 5' …ACAAUGAAAUAUUGCUGUAUAGCUCCUU… 3' | [61] |
All listed studies assessed the interaction of miRNA and the specific target sequence by luciferase reporter assay. Sequences represented in bold and underline correspond to the binding nucleotides between mRNA and cognate miRNA.