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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Semin Cancer Biol. 2021 May 9;76:120–131. doi: 10.1016/j.semcancer.2021.05.004

Table 1:

Experimental evidence for targeting of mRNA 3’UTRs by cognate miRNAs*

miRNA TargetGene Binding Sequence on Target Reference
miR-210 E2F3 5' …UGUCUAAACGCACA… 3' [60]
miR-148a-3p CD274(PD-L1) 5' …GCACUG… 3' [96]
miR-129-5p SOX4 5' …GCAAAA… 3' [98]
miR-129-3p SOX4 5' …AAGGGCU… 3' [98]
miR-21 MSH2 5' …AUAAGCUA… 3' [99]
miR-155 MLH1 Not Described [97]
miR-155 MSH2 Not Described [97]
miR-155 MSH6 Not Described [97]
miR-497 SSRP1 5' …ACUCUGCUGCU… 3' [71]
miR-497 SSRP1 5' …AGGAUGUAG-CUGCUGCU… 3' [71]
miR-146a-5p MALAT1 5' …AGUUCUC… 3' [128]
miR-216b-5p MALAT1 5' …TAGAGAU… 3' [128]
miR-22 MDC1 5' …UGUCAUAAGUGGCAGCU… 3' [140]
miR-222 RAD51 Not Described [141]
miR-205 RAD17 5' …GAUGUGAAGG… 3' [132]
miR-205 BRCA1 5' … GACUUCUG-GCUAUGCAAGG… 3' [132]
miR-128-3p SPTAN1 5'…AUCAUGUCACUGUGG…3' [122]
miR-138 H2AX 5'… CAAGCACCUAGAUACCAGC… 3' [126]
miR-214 RNF8 5'…CAACCUGCUG…3' [129]
miR-223-3p PARP-1 5'…GGUAGAU..A..AAACUGAC.. [75]
miR-223-3p CTIP 5'…CCG..A.AAGUAAAACGUGAGA..3' [75]
miR-223-3p PSO4 5'…AUGACCAGCUUAAAACUAGCU..3' [75]
miR-26a CHFR 5' …UCUGGAAUAAUACUUGAA… 3' [58]
miR-509-3-5p PLK1 5' …GUGCCAUGUCUGCAGUG… 3' [160]
miR-193a-3p RASSF1 5' …GUGUGAGUGUGACAGGGCCAGUGG… 3' [161]
let-7b Aurora B 5' … UCCCUUAUCUGUUUUCUACCUCC… 3' [62]
miR-155 BUB1 5' …CCCTTGTT.CCCTTAGCATTA… 3' [77]
miR-125b MAD 1 5' …UGCAUCAAUCGGACUCGGGGGC… 3' [163]
miR-493-3p MAD 2 5' …CCUUUUGACCUUCAU… 3' [63]
miR-28-5p MAD 2 5' …ACAAUGAAAUAUUGCUGUAUAGCUCCUU… 3' [61]
*

All listed studies assessed the interaction of miRNA and the specific target sequence by luciferase reporter assay. Sequences represented in bold and underline correspond to the binding nucleotides between mRNA and cognate miRNA.