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. 2021 Oct 26;11:751183. doi: 10.3389/fonc.2021.751183

Table 2.

Three subfamilies of KIRs and specific ligands.

Group a HLA-class I specificity b
KIR2DL1(CD158a) C2(-Cw2, -Cw4, -Cw5, -Cw6)
KIR2DL2/3(CD158b1/b2) C1(-Cw1, -Cw3, -Cw7, -Cw8)
KIR3DL1(CD158e1) Bw4(-B27, -B51)
a

Each group compromises different numbers of alleles, which differ by 1-9 nucleotide substitutions (22).

b

Two groups of HLA-C alleles are distinguished by dimorphic positions Ser 77–Asn 80 (C1) and Asn 77–Lys 80 (C2) of the α1 helix (23). HLA-B allotypes share the Bw4 sequence motif at positions 77–83 of the α1 helix (22).