Table 3.
Applications of NK cells in glioma.
| Targets | NK Source | CAR construct | Tumors | Phase | Reference/NCT |
|---|---|---|---|---|---|
| EGFRvIII | NK92 cell line | scFv-CD28TM+IC-CD3ζ | Glioblastoma | / | Genßler et al. (118) |
| EGFRvIII | YTS NK cell line | scFv-DAP12 TM+IC | Glioblastoma | / | Müller et al. (90) |
| EGFRvIII | KHYG-1 NK cell line | scFv-CD28 TM+IC-CD137-CD3ζ | Glioblastoma | / | Murakami et al. (119) |
| EGFRvIII | NK92 cell line | scFv-CD28 TM+IC-CD3ζ | Glioblastoma | / | Han et al. (120) |
| HER2 | NK92 cell line | scFv-CD3 TM+IC | Glioblastoma | / | Alkins et al. (121) |
| HER2 | NK92 cell line | scFv-CD28 TM+IC-CD3ζ | Glioblastoma | / | Zhang et al. (122) |
| HER2 | NK92 cell line | scFv-CD28-CD3ζ | Glioblastoma | I | NCT03383978 |
| HER2 | NK92 cell line | Unknown | Glioblastoma | I | NCT03383978 |
| MUC1 | Unknown | Unknown | High Grade Glioma | I/II | NCT02839954 |
| None | PBMCs | None | High Grade Glioma | I | NCT04254419 |
| None | PBMCs | None | Glioma | I | NCT00909558 |
| None | Placenta | None | High Grade Glioma | I | NCT04489420 |