Figure 4.

Overview of our network medicine approach

(A) The human interactome containing both host proteins (red) and drug targets (blue).

(B) The totals of 14,941 drug target associations between N = 2,197 FDA-approved drugs and n_V = 18,505 proteins are represented by a binary matrix T (blue matrix). Multiple graph kernels are calculated on the interactome, resulting in $n_V\times n_V$ matrices (green matrices). The host proteins are represented by a vector h of size $n_V$ (red vector) indicating their weights (based on gene expression data).

(C) Our kernel score is calculated using a matrix multiplication to obtain a prediction score for each drug.

(D) The obtained ranking is evaluated using different types of evidence: in vitro efficacy against SARS-CoV-2, Connectivity Map, and clinical trials.