Figure 6.

Screenshot of CoREx displaying a functional module for Sulfasalazine (highlighted in green in the “Drug” list)

The module is depicted as a network on the top left where nodes represent proteins, edges represent shared functional characteristics, and the thickness of the edges represents the strength of such functional similarity. Host proteins are depicted as diamonds, drug targets are colored. The list of drugs with at least one target in this functional module is presented in the center, alongside CMAP scores for five cell lines (on the left), and an indicator of whether the drug is currently in clinical trials (on the right). The bar plots on the right part correspond to the functional enrichment scores for each GO domain. The bar plot on the bottom left section of the image summarizes the ATC categories of the drugs targeting this functional module.