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. 2021 Oct 26;15:752958. doi: 10.3389/fnins.2021.752958

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Copyright © 2021 Thomas, Lin, Martinez-Camarillo, Zhu, McLelland, Nistor, Keirstead, Humayun and Seiler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Retina organoid + RPE implant on matrigel. (A) RO and RPE embedded together using matrigel. (B) Plastic section of tissue fixed 1 h after matrigel embedding. (C) After co-culture for 4 days, arrow points to retina organoid. (D) Optical coherence tomography (OCT) B-scan image 12 days after transplantation of the co-graft into a rat eye (A). Arrow indicates parylene implant. (E) OCT fundus image showing the co-graft placement in the subretinal area of an RCS rat; arrows point to co-graft. (F) Histology of the transplanted eye (hematoxylin–eosin staining). Arrows point to parylene implant. (G) Staining for human nuclei (Ku-80). (H) Recoverin: photoreceptors and cone bipolar cells. (I) Staining for cellular retinaldehyde binding protein (CRALBP: Müller glia and RPE).