Table 2. Mutation and biomarker incidence.
| Name | Incidence (%) | Incidence ratio | Technique |
|---|---|---|---|
| MSH2 | 100 | 92/92 | IHC |
| MSH6 | 100 | 90/90 | IHC |
| MLH1 | 98.9 | 91/92 | IHC |
| PMS2 | 98.9 | 87/88 | IHC |
| EGFR | 97.7 | 43/44 | IHC |
| PD-1 | 68.8 | 44/64 | IHC |
| PTEN | 68.1 | 64/94 | IHC |
| PD-L1 | 40.5 | 119/294 | IHC |
| PIK3CA | 28.1 | 62/221 | NGS |
| PIK3CA | 24.2 | 15/62 | NGS hot spot |
| KMT2D | 19.5 | 36/185 | NGS |
| KMT2C | 16.2 | 19/177 | NGS |
| FBXW7 | 12.9 | 8/62 | NGS hot spot |
| TP53 | 12. | 25/208 | NGS |
| PTEN | 10.8 | 22/204 | NGS |
| FBXW7 | 10.3 | 20/195 | NGS |
| TMB | 6.7 | 14/209 | NGS |
| PIK3CA | 5.4 | 11/205 | CNA |
| TP53 | 5 | 3/60 | NGS hot spot |
| ARID1A | 4.8 | 4/84 | NGS |
| ATRX | 4.1 | 3/73 | NGS |
| APC | 3.8 | 8/212 | NGS |
| NOTCH1 | 3.4 | 7/204 | NGS |
| RB1 | 3.3 | 2/61 | NGS hot spot |
| AKT1 | 3.2 | 2/62 | NGS hot spot |
| KRAS | 3.2 | 2/62 | NGS hot spot |
| TRK A/B/C | 3.1 | 2/64 | IHC |
| BCL6 | 2.9 | 6/205 | CNA |
| NFIB | 2.9 | 6/205 | CNA |
| PBRM1 | 2.9 | 6/206 | NGS |
| EP300 | 2.9 | 5/174 | NGS |
| CDKN2A | 2.8 | 6/216 | NGS |
| KRAS | 2.7 | 6/221 | NGS |
| FGF19 | 2.5 | 5/204 | CNA |
| TFRC | 2.4 | 5/205 | CNA |
| FGF4 | 2.4 | 5/208 | CNA |
| FGF3 | 2.4 | 5/209 | CNA |
| KDM5C | 2.4 | 3/126 | NGS |
| FGFR3 | 2.3 | 5/214 | NGS |
| AKT1 | 2.3 | 5/218 | NGS |
| BAP1 | 2.3 | 5/219 | NGS |
| CYLD | 2.1 | 4/191 | NGS |
| RB1 | 2 | 4/197 | NGS |
| PIK3R1 | 2 | 4/204 | NGS |
| KLHL6 | 2 | 4/205 | CNA |
| CCND1 | 1.9 | 4/210 | CNA |
| BRCA2 | 1.9 | 4/215 | NGS |
| MUTYH | 1.8 | 4/217 | NGS |
| ERBB2 | 1.8 | 4/219 | NGS |
| ZNF703 | 1.5 | 3/203 | CNA |
| CALR | 1.5 | 3/205 | CNA |
| ETV5 | 1.5 | 3/205 | CNA |
| LPP | 1.5 | 3/205 | CNA |
| LYL1 | 1.5 | 3/205 | CNA |
| PSIP1 | 1.5 | 3/205 | CNA |
| SMAD2 | 1.5 | 3/205 | CNA |
| EGFR | 1.4 | 3/208 | CNA |
| FH | 1.4 | 3/215 | NGS |
| CTNNB1 | 1.4 | 3/216 | NGS |
| HRAS | 1.4 | 3/221 | NGS |
| MSI | 1.3 | 2/156 | NGS |
| CREBBP | 1.1 | 2/188 | NGS |
| NSD1 | 1 | 2/198 | NGS |
| ARID2 | 1 | 2/200 | NGS |
| MYB | 1 | 2/202 | CNA |
| ADGRA2 | 1 | 2/203 | CNA |
| FANCG | 1 | 2/204 | CNA |
| PRRX1 | 1 | 2/204 | CNA |
| KEAP1 | 1 | 2/205 | CNA |
| KRAS | 1 | 2/205 | CNA |
| MALT1 | 1 | 2/205 | CNA |
| NSD3 | 1 | 2/205 | CNA |
| SMAD4 | 1 | 2/205 | CNA |
| SS18 | 1 | 2/205 | CNA |
| FGFR1 | 1 | 2/209 | CNA |
| MSH6 | 1 | 2/210 | NGS |
| ERCC2 | 0.9 | 2/213 | NGS |
| ATM | 0.9 | 2/214 | NGS |
| STK11 | 0.9 | 2/216 | NGS |
| BRAF | 0.9 | 2/217 | NGS |
| ERBB3 | 0.9 | 2/218 | NGS |
| BRCA1 | 0.9 | 2/219 | NGS |
IHC, immunohistochemistry; NGS, next-generation sequencing; CNA, copy number alteration.