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Structure of epithelial glycocalyx and tight junction. Epithelium was covered with a layer of glycocalyx, whose main component is SDC-1 (A). Tight junction proteins consist of the integral transmembrane protein occludin and intracellular protein ZO-1 and other accessory proteins (A). The ZO-1 binds to the cytoplasm of occludin. When the structures of the glycocalyx and tight junction proteins were damaged, albumin leakage occurred (B).
