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. 2021 Oct 26;12:734745. doi: 10.3389/fimmu.2021.734745

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Copyright © 2021 Deng, Hu, Dai, Yuan, Hu and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–F) The linkages between the risk grouping and some common chemotherapy agents for BC, for example, (A) cisplatin, (B) vinblastine, (C) docetaxel, (D) cyclopamine, (E) doxorubicin, and (F) gemcitabine. (G–K) Analyses of the relationship of ICs with the risk score, including (G) PDCD1, (H) CTLA4, (I) LAG3, (J) CD27, and (K) IDO1. (L) The waterfall diagram of the altered genes in 625 samples. (M) The survivorship curve indicates that patients with low TMB scores have a longer survival time (P = 0.0024). (N) The boxplot reflects the correlation between the risk cluster and the TMB score (p = 0.0024). (O) There was a positive association between the risk clusters and TMB clusters (p = 0.00087).*p < 0.05, ***p < 0.001.