FIGURE 3.

The Dorsal Cochlear Nucleus and Tinnitus Mechanisms. Tinnitus mice display increased spontaneous firing of fusiform cells (FC). This is due to enhanced intrinsic excitability due to a shift in the voltage dependence of KCNQ2/3 channels. Adapted from Ref. 48, with permission from Proceedings of the National Academy of Sciences of the USA. Additional contributors are reductions in GABAergic and glycinergic signaling and aberrant spike timing-dependent plasticity (STDP)-like plasticity. Tinnitus-related changes are depicted in red. CWC, cartwheel cells.