FIGURE 4.

Thalamocortical dysrhythmia in tinnitus. A: peripheral deafferentation causes a reduction of input from the peripheral auditory system that is sent to the medial geniculate body (MGB). B: hyperpolarization and decreased excitatory input to the thalamic neurons causes the firing mode to switch from tonic to burst firing due to de-inactivation of T-type calcium channels. C: as a result of the switch to burst firing, low-frequency oscillations are generated and propagated to the auditory cortex. D: low-frequency oscillations in the deafferented area of cortex leads to a reduction of inhibition to adjacent columns generating high frequency oscillations (Edge effect).