Table 3.

Association Between AD-GRS and Body Mass Index Stratified by Age^a, UK Biobank, United Kingdom, 2006–2010

		Primary AD-GRS 2013 Score b		2019 Score c
Age Group, years	No.		95% CI		95% CI
39–49	88,758	0.00	−0.03, 0.03	0.00	−0.04, 0.02
50–59	134,163	−0.03	−0.06, −0.01	−0.04	−0.07, −0.01
60–73	184,465	−0.09	−0.12, −0.07	−0.09	−0.11, −0.07

Abbreviations: AD-GRS, Alzheimer’s disease genetic risk score; CI, confidence interval; GWAS, genome-wide association study; SNP, single nucleotide polymorphism.

^a Reaction time was measured in milliseconds. Models adjusted for age, age², sex, and principle components to account for confounding by population stratification.

^b AD-GRS of 23 SNPs using estimates from 2013 GWAS meta-analysis.

^c AD-GRS of 27 SNPs using estimates from 2019 GWAS meta-analysis.