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. 2021 Jun 15;70(9):2120–2130. doi: 10.2337/db20-1260

Figure 3.

Figure 3

ALOX5 expression positively correlates with ACE2 expression in individuals with diabetes and COVID-19, and this is associated with an increased rate in ICU admissions. A: Correlation matrix between ALOX5 and ACE2/TMPRSS2 expression in PBMCs from DM (red) and NDM (gray) patients. B: Correlation analysis between ACE2 and TMPRSS2 expressions in PBMCs of NDM (B) and DM (C) individuals with COVID-19. D: Correlation analysis between ALOX5 and ACE2 expression in PBMCs from DM patients. E to G: Hospitalization type among DM or NDM individuals with COVID-19 based on the expression of ACE2, ALOX5 and TMPRSS2. Data are medians. Spearman r correlation. *P < 0.05, **P < 0.01.