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. 2021 Jun 27;70(9):1945–1955. doi: 10.2337/dbi21-0003

Figure 1.

Figure 1

Combined DVC single-cell transcriptomics atlas highlights distinct groups of incretin receptor cells. A: Graphical illustration of snRNA-seq of the DVC. B: UMAP plot of 75,785 DVC cells from two independent studies (15,16). The receptors found among the top 100 most specifically expressed genes in oligodendrocytes, the only incretin receptor–expressing glial cell type, are plotted by the normalized transcript counts in the focal cell type (green) and remaining cells (gray). C: UMAP plot of 51,212 DVC neurons from the combined atlas. The cell population classifications from the atlas provided by Ludwig et al. (16) have been maintained except for Glu4 neurons, which were split into three clusters (Glu4a-c) following the classification by Zhang et al. (15). The expression of receptors being part of the top 100 most specifically expressed genes in incretin receptor–expressing neurons is depicted in terms of the normalized transcript counts in the focal neuronal population (red, AP; blue, NTS) and remaining neurons (gray). OPCs, oligodendrocyte precursor cells; VLMCs, vascular and leptomeningeal cells.