Figure 1.

Schematic depiction of the antiobesity effects induced by central GIP agonism or antagonism. The weight loss effect is induced by either central administration of a long-acting GIP derivative, a neutralizing GIPR antibody, or genetic loss of brain GIPR. Interestingly, both central GIP agonism and antagonism have an effect on food intake but not on energy expenditure. Thus reduced energy intake is likely to account for the GIP-mediated weight loss.