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. 2021 Feb 24;70(9):2042–2057. doi: 10.2337/db20-0572

Figure 8.

Figure 8

Effects of TREM2 on hepatic steatosis are linked to nonhematopoietic tissue and elevated adipose ceramide levels. A: Liver aspects and stainings of representative liver sections (hematoxylin-eosin [H&E], oil red O, ceramide) and representative whole mount of eWAT of BM-transplanted mice 26 weeks post-HFD. B: Liver steatosis in groups of BM-transplanted mice 26 weeks post-HFD. C: Serum levels of ALT 26 weeks post-HFD. D: Average abundance of short-, long-, and ultra-long-chain ceramide species in eWAT of BM-transplanted mice 26 weeks post-HFD. Individual ceramide abundances scaled between 0 (minimum) and 1 (maximum) (n = 4 mice per genotype). E: Serum adiponectin levels 26 weeks post-HFD. Data are mean ± SEM (B, C, and E) and pooled from two independent experiments (n = 10–13 mice per genotype). Statistical analysis was performed with one-way ANOVA followed by Tukey posttest (B, C, and E). *P < 0.05, **P < 0.01, ***P < 0.01.