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. 2021 Jun 15;70(9):2058–2066. doi: 10.2337/db21-0211

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© 2021 by the American Diabetes Association

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Different transcriptional trajectories in β-cell maturation in development and their dedifferentiation in different types of diabetes. PCA of the top 15% most variable genes between β-cell transcriptomes during development and dedifferentiation is shown. Left: β-cells in diabetes cluster away from β-cells of healthy adult mice but do not cluster with any developmentally relevant stage, indicating that β-cell dedifferentiation is not a reversal of developmental ontogeny. Right: view of the trajectory map from another angle, showing separation between β-cell states in T1D and T2D.