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. 2021 Oct 26;11:740557. doi: 10.3389/fonc.2021.740557

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Copyright © 2021 Zheng, Gou, Jiang, Yang, Yang and Qin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FAM99A blocked the JAK2/STAT3 pathway via promoting SOCS3. (A) miRNAs binding to both FAM99A and SOCS3 in HCC cells were sorted. (B) RNA pull-down assay was conducted to detect the enrichment of miR-145-5p and miR-299-5p in the pull-down of biotinylated FAM99A in HCC cells. (C) The overexpression efficiency of miR-299-5p was detected by qRT-PCR. (D) Expression of FAM99A and SOCS3 in HepG2 cells transfected with miR-299-5p mimics was detected. (E) Luciferase reporter assay was used to verify the relationship between FAM99A/SOCS3 and miR-299-5p. ^** p < 0.01, ns, no significance.