Table 1.
Baseline demographic and clinical characteristics
| Total cohort (n=962*) | MLH1 carriers (n=204) | MLH1 non-carrier controls (n=199) | MSH2 carriers (n=305) | MSH2 non-carrier controls (n=210) | MSH6 carriers (n=135) | MSH6 non-carrier controls (n=177) | |
|---|---|---|---|---|---|---|---|
| Age, years | |||||||
| 40–49 | 369 (38%) | 76 (37%) | 67 (34%) | 133 (44%) | 77 (37%) | 50 (37%) | 62 (35%) |
| 50–59 | 358 (37%) | 78 (38%) | 79 (40%) | 101 (33%) | 76 (36%) | 54 (40%) | 70 (40%) |
| 60–69 | 235 (24%) | 50 (25%) | 53 (27%) | 71 (23%) | 57 (27%) | 31 (23%) | 45 (25%) |
| Median | 53 (46–59) | 52 (46–59) | 54 (46–54) | 51 (45–59) | 54 (46–60) | 54 (46–60) | 53 (46–59) |
| Mean | 52·8 (8·3) | 52·7 (8·2) | 53·9 (8·2) | 51·9 (8·2) | 53·5 (8·6) | 53·6 (8·2) | 52·9 (8·0) |
| p value for difference in mean between carriers and non-carrier controls | NA | 0·15 | .. | 0·036 | .. | 0·42 | .. |
| Qualifications | |||||||
| No qualifications | 61/910 (6%) | 15/196 (8%) | 16/187 (9%) | 11/286 (4%) | 18/198 (9%) | 8/129 (6%) | 13/168 (8%) |
| Attended school up to age 16 years | 172/910 (19%) | 34/196 (17%) | 34/187 (18%) | 60/286 (21%) | 38/198 (19%) | 20/129 (16%) | 28/168 (17%) |
| Attended school up to age 18 years or College degree | 82/910 (9%) | 18/196 (9%) | 24/187 (13%) | 20/286 (7%) | 26/198 (13%) | 8/129 (6%) | 24/168 (14%) |
| Technical or vocational qualification | 180/910 (20%) | 32/196 (16%) | 47/187 (25%) | 53/286 (19%) | 45/198 (23%) | 23/129 (18%) | 40/168 (24%) |
| University graduate | 372/910 (41%) | 81/196 (41%) | 63/187 (34%) | 127/286 (44%) | 71/198 (36%) | 64/129 (50%) | 60/168 (36%) |
| Other qualification | 43/910 (5%) | 16/196 (8%) | 3/187 (2%) | 15/286 (5%) | 0 | 6/129 (5%) | 3/168 (2%) |
| Unknown | 52 | 8 | 12 | 19 | 12 | 6 | 9 |
| Ethnicity | |||||||
| European ancestry | 899/953 (94%) | 176/201 (88%) | 192/199 (96%) | 287/304 (94%) | 206/209 (99%) | 130/132 (98%) | 174/176 (99%) |
| Black African or Black Caribbean ancestry | 5/953 (1%) | 1/201 (<1%) | 0 | 4/304 (1%) | 0 | 0 | 0 |
| Asian ancestry | 37/953 (4%) | 18/201 (9%) | 6/199 (3%) | 10/304 (3%) | 2/209 (1%) | 1/132 (1%) | 2/176 (1%) |
| Mixed | 12/953 (1%) | 6/201 (3%) | 1/199 (1%) | 3/304 (1%) | 1/209 (<1%) | 1/132 (1%) | 0 |
| Unknown | 9 | 3 | 0 | 1 | 1 | 3 | 1 |
| Family history of prostate cancer (self-reported)† | |||||||
| Yes | 186 (19%) | 31 (15%) | 49 (25%) | 56 (18%) | 58 (28%) | 29 (21%) | 47 (27%) |
| No | 776 (81%) | 173 (85%) | 150 (75%) | 249 (82%) | 152 (72%) | 106 (79%) | 130 (73%) |
| p value for difference between carriers and non-carrier controls | NA | 0·0044 | .. | 0·028 | .. | 0·081 | .. |
| Previous urinary symptoms | .. | ||||||
| Yes | 208/949 (22%) | 43/203 (21%) | 53 (27%) | 55/302 (18%) | 42/207 (20%) | 33/131 (25%) | 42/175 (24%) |
| No | 741/949 (78%) | 160/203 (79%) | 146 (73%) | 247/302 (82%) | 165/207 (80%) | 98/131 (75%) | 133/175 (76%) |
| Unknown | 13 | 1 | 0 | 3 | 3 | 4 | 2 |
| p value for difference between carriers and non-carrier controls | NA | 0·24 | .. | 0·57 | .. | 0·89 | .. |
| Previous PSA test | |||||||
| Yes | 318/834 (38%) | 71/168 (42%) | 76/181 (42%) | 92/266 (35%) | 72/189 (38%) | 45/116 (39%) | 68/154 (44%) |
| No | 516/834 (62%) | 97/168 (58%) | 105/181 (58%) | 174/266 (65%) | 117/189 (62%) | 71/116 (61%) | 86/154 (56%) |
| Unknown | 128 | 36 | 18 | 39 | 21 | 19 | 23 |
| p value for difference between carriers and non-carrier controls | NA | 0·99 | .. | 0·49 | .. | 0·39 | .. |
Data are n (%), n/N (%), n, median (IQR), mean (SD), or p value. PSA=prostate-specific antigen.
*
BRCA1 and BRCA2 non-carrier controls were included in every non-carrier control group but only counted once in the total cohort number; therefore, the sum of each genetic cohort does not equal the total.
†
First-degree or second-degree relative with prostate cancer.