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. 2021 Nov 8;8(1):e000765. doi: 10.1136/bmjgast-2021-000765

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Transcriptome comparison of DGAST and PNET. (A) Schematic of DGAST and PNET RNA-seq comparison. (B) PCA in three dimensions of DGAST, PNET, nDUO and nPANC. (C) Pearson’s correlation coefficients (R²) for each normal tissue and GEP-NETs, R² >0.8=biological replicate. (D) Coexpression Venn diagram of patient samples, with default threshold of FPKM set to 1 in each group. (E) Heatmap of DEGs in DGAST (n=4), PNET (n=6), nDUO (n=3) and nPANC (n=2). DGAST, duodenal gastrinoma; FPKM, fragments per kilobase of transcript per million mapped reads; GEP-NETs, gastroenteropancreatic neuroendocrine tumours; nDUO, normal duodenum; nPANC, normal pancreas; PC, principal component; PCA, principal component analysis; PNET, pancreatic neuroendocrine tumour; RNA-seq, RNA-sequencing.