Figure 2.

Palmitate R_a in plasma and plasma palmitate concentration. Basal palmitate R_a in plasma, an index of adipose tissue lipolytic rate, expressed in relation to fat mass (A) and fat-free mass (B); the relationships between plasma insulin concentration during both basal conditions and the hyperinsulinemic-euglycemic clamp procedure and palmitate R_a in plasma expressed in relation to fat mass (C), fat-free mass (D), and basal plasma palmitate concentration (E); and relationship between palmitate R_a in plasma and plasma palmitate concentration (F) in healthy lean participants and participants with obesity who were grouped, by quartiles, according to insulin-simulated whole-body glucose uptake rate. Values are expressed as mean ± SEM (upward error bar only) or median (IQR). ANOVA was used to evaluate differences in outcome variables among groups in A, B, and E. Skewed data sets were log transformed to achieve normal distribution before analysis. Curve fitting was used to evaluate the relationships between outcome variables in panels C, D, and F. Bars not sharing letters are significantly different from each other, P < 0.05. *Significant main effect of obesity, P < 0.05. FFM, fat-free mass; FM, fat mass; OIR, obese insulin-resistant (Q3/4); OIS, obese insulin-sensitive (Q1).