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. 2021 Aug 3;70(10):2264–2274. doi: 10.2337/db21-0126

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© 2021 by the American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

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Effects of chronic ICV leptin or vehicle infusion on food intake, net cumulative food intake, body weight, and plasma hormones in parabiotic rats. Food intake (A), net cumulative food intake (B), body weight (C), fasting blood leptin (D), and insulin concentrations (E) measured during baseline, day 5 after STZ injection, day 7 of leptin or vehicle infusion, and last day of recovery periods in parabiotic rats. Values for food intake and body weight represent the sum of the pair and not for each individual rat. *P < 0.05 compared with Veh-Veh group using two-way ANOVA; #P < 0.05 compared with baseline using one-way ANOVA with repeated measures.