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. 2021 Aug 3;70(10):2264–2274. doi: 10.2337/db21-0126

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© 2021 by the American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

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Effects of chronic ICV leptin or vehicle infusion on blood glucose and liver gluconeogenesis in parabiotic rats. A: Average of the last 3 days of blood glucose during control, STZ, leptin, or vehicle treatment and recovery periods. Daily blood glucose concentration (B), liver R_t (C), R_a (D), and R_d (E) in responses to ICV leptin or vehicle in conjoined rats. *P < 0.05 compared with Veh-Veh group using two-way ANOVA or one-way ANOVA as appropriate; #P < 0.05 compared with baseline using one-way ANOVA with repeated measures.