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. 2021 Aug 3;70(10):2264–2274. doi: 10.2337/db21-0126

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© 2021 by the American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

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Effects of chronic ICV leptin infusion on GLUT4 plasma membrane expression and key proteins involved in glucose and fatty acid oxidation in skeletal muscle of parabiotic rats. A: GLUT4. B: p-Akt/Akt ratio. C: p-AMPK/AMPK ratio. D: p-mTOR/mTOR ratio. E: PGC1α. F: p-ACC/ACC. G: p-PDH/PDH. H: FBP1 protein expression in diabetic ICV vehicle-treated only, leptin, or vehicle-conjoined treated rats. *P < 0.05 compared with diabetic Veh-Veh using one-way ANOVA; †P < 0.05 compared with ICV leptin-infused partner using one-way ANOVA.