FIG 4.

Diversity between IOL and Asian lineage CHIKV envelope glycoproteins. The immature envelope glycoprotein complex of CHIKV (from PDB accession number 3N40) is shown. The E1 protein is in light blue, the E2 protein is in light red, and the E3 protein is in yellow. Residues that differ between SL07 (IOL) and Mal06 (Asian lineage) envelope proteins are shown as spheres. In addition, the IOL adaptive mutations E2-198, E2-210, E2-233, E2-252, as well as E3-33 are shown as spheres and highlighted in red despite their having the same amino acids in the SL07 and Mal06 backbones. Residue E1-226 is shown as spheres highlighted in cyan. Residues of particular interest are highlighted with labels and arrows.