FIG 12.

Model of spatial organization of an HPV replication focus in HPV16 wild-type and ΔE8^E2 genome-containing cells. On the left, HPV genomes in the center of the replication focus are associated with the viral E8^E2 and cellular macroH2A1 repressor proteins, and active chromatin is restricted to the surface of the foci. On the right, cells with HPVΔE8^E2 genomes do not express the E8^E2 protein (and so do not recruit cellular corepressors to the foci). The macroH2A1 variant histone is also absent from these foci, and active chromatin is found throughout the focus.