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Effects of Berberine on PCSK9, p-ERK and ERK protein expressions in HepG2 cells (A,B). U0126, the ERK1/2 inhibitor, attenuated the decreased PCSK9 expression induced by Berberine in HepG2 cells (C,D). *P<0.05, **P<0.01, ***P<0.001: BBR vs. control; ##P<0.01: BBR + U0126 vs. BBR.
