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. 2021 Oct;9(20):1573. doi: 10.21037/atm-21-4978

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Transplantation of either AMSCs-miR-449 or AMSCs-shPLOD1 decreases the fibrosis after skin injury in mice. (A,B) The effects of transplantation of AMSCs-miR-449, AMSCs-shPLOD1 and control AMSCs-scr on the fibrosis were evaluated by Masson-trichrome staining 2 weeks after the skin injury in mice, shown by representative images (A), and quantification (B). *, P<0.05. N=10. Scale bars are 50 µm. ns, not significant; AMSCs, adipose-derived mesenchymal stem cells; PLOD1, procollagen-lysine 1,2-oxoglutarate 5-dioxygenase 1; scr, scrambled sequence.