Table 3. Univariate and multivariate analysis for disease-free survival in relation to clinicopathological parameters.
| Variables | All patients (n=182)a | ||||
|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | ||||
| HR, 95% CI | P value | HR, 95% CI | P value | ||
| Age | 0.977 | 0.966 | |||
| ≤60 | 1.00 | 1.00 | |||
| >60 | 1.01 (0.57–1.77) | 1.01 (0.55–1.88) | |||
| Gender (female vs. male) | 0.071 | 0.078 | |||
| Male | 1.00 | 1.00 | |||
| Female | 0.46 (0.20–1.07) | 0.47 (0.20–1.09) | |||
| Tumor location | 0.860 | 0.561 | |||
| Proximal third | 1.00 | 1.00 | |||
| Middle third | 0.82 (0.40–1.69) | 0.72 (0.34–1.52) | |||
| Distal third | 0.82 (0.35–1.91) | 0.25 (0.22–1.52) | |||
| Clinical T stage | 0.787 | 0.275 | |||
| T1–T2 | 1.00 | 1.00 | |||
| T3 | 1.06 (0.53–2.13) | 0.88 (0.43–1.80) | |||
| T4 | 1.26 (0.58–2.73) | 1.58 (0.65–3.82) | |||
| Clinical N stage | 0.685 | 0.081 | |||
| N0 | 1.00 | 1.00 | |||
| N1 | 1.18 (0.54–2.58) | 2.39 (0.90–6.33) | |||
| Pathological complete response | <0.001 | <0.001 | |||
| Non-pCR | 1.00 | 1.00 | |||
| pCR | 0.36 (0.21–0.63) | 0.36 (0.20–0.62) | |||
| Incision | 0.724 | 0.403 | |||
| Right thoracoabdominal incision | 1.00 | 1.00 | |||
| Three-incision thoracotomy | 0.78 (0.19–3.18) | 0.54 (0.13–2.29) | |||
| Nodes examined (>19 vs. ≤19) | 0.008 | 0.003 | |||
| ≤19 | 1.00 | 1.00 | |||
| >19 | 0.52 (0.32–0.84) | 0.45 (0.27–0.76) | |||
| CRT cycle | 0.252 | 0.398 | |||
| 1 cycle | 1.00 | 1.00 | |||
| 2 cycles | 0.66 (0.33–1.34) | 0.71 (0.33–1.56) | |||
a, three patients who did not achieve R0 resection were not included in the analysis. BMI, body mass index; CI, confidence interval; CRT, chemoradiotherapy; HR, hazard ratio; pCR, pathological complete response.