Table 3. Univariate and multivariate Cox regression analysis of the clinicopathological features and potential models in this study.
| Variables | Patients (n=504), n (%) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |||
| Age (years) | 1.25 (0.881–1.791) | 0.207 | ||||
| 60 | 387 (76.79) | |||||
| ≤60 | 108 (21.43) | |||||
| Missing# | 9 (1.79) | |||||
| Gender | 1.197 (0.871–1.644) | 0.266 | ||||
| Male | 373 (74.01) | |||||
| Female | 131 (25.99) | |||||
| TNM stage | 1.560 (1.135–2.143) | 0.006** | 1.237 (0.780–1.964) | 0.366 | ||
| Stage I/II | 408 (80.95) | |||||
| Stage III/IV | 92 (18.25) | |||||
| Missing# | 4 (0.79) | |||||
| M status | 3.065 (1.253–7.500) | 0.014* | 2.316 (0.886–6.054) | 0.086 | ||
| M0 | 414 (82.14) | |||||
| M1 | 7 (1.39) | |||||
| Missing# | 83 (16.47) | |||||
| N status | 1.151 (0.872–1.520) | 0.318 | ||||
| N0 | 320 (63.49) | |||||
| N1–N3 | 178 (35.32) | |||||
| Missing# | 6 (1.19) | |||||
| T status | 1.648 (1.196–2.270) | 0.0022** | 1.369 (0.858–2.182) | 0.1872 | ||
| T1–T2 | 409 (81.15) | |||||
| T3–T4 | 95 (18.85) | |||||
| Smoking grade | 1.540 (1.161–2.042) | 0.0027** | 1.699 (1.240–2.3309) | 0.00098** | ||
| Grade 1–2 | 152 (30.16) | |||||
| Grade 3–5 | 340 (67.46) | |||||
| Missing# | 12 (2.38) | |||||
| FTO (eraser) | 1.175 (0.986–1.400) | 0.069 | ||||
| Low | 252 (50.00) | |||||
| High | 252 (50.00) | |||||
| FTO (CNV) | 0.783 (0.464–1.321) | 0.359 | ||||
| Loss | 15 (50.00) | |||||
| Gain | 18 (50.00) | |||||
| METTL3 (writer) | 0.932 (0.769–1.130) | 0.477 | ||||
| Low | 252 (50.00) | |||||
| High | 252 (50.00) | |||||
| METTL3 (CNV) | 0.917 (0.663–1.268) | 0.601 | ||||
| Loss | 43 (50.00) | |||||
| Gain | 44 (50.00) | |||||
| KIAA1429 (writers) | 1.177 (0.970–1.426) | 0.098 | ||||
| Low | 249 (50.30) | |||||
| High | 246 (49.70) | |||||
| Two-gene model (FTO + METTL) | 1.44 (1.095–1.891) | 0.0089** | 1.634 (1.038–2.572) | 0.0014** | ||
| Low | 246 (48.81) | |||||
| High | 249 (49.40) | |||||
#, ambiguous variables (missing) were excluded. *, P<0.05; **, P<0.01. HR, hazard ratio; CI, confidence interval; TNM, tumor, node and metastasis; CNV, copy number variant.