FIGURE 4.

Viral vector‐mediated expression of lactate oxidase (LOx) in astrocytes as a novel tool for accelerated breakdown of intracellular lactate. Constitutive activity of LOx breaks down lactate produced through glycolysis in astrocytes and, consequently, decreases intra‐astrocytic lactate concentration and subsequent release to the extracellular space. This has implications for constitutive as well as stimulus‐evoked lacatate release and for metabolic and signaling roles of lactate in the brain [Color figure can be viewed at wileyonlinelibrary.com]