TABLE 3.
Results of univariable logistic regression analyses of orotracheal intubation risk in patients with awake prone positioning
| Unmatched | Matched | |||
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Awake prone | 0.46 (0.34–0.62) | <0.0001 | 0.50 (0.36–0.71) | <0.0001 |
| Demographic variables | ||||
| Age (years) | 1.02 (1.004–1.03) | 0.007 | 1.01 (1.002–1.03) | 0.02 |
| Sex (male) | 0.91 (0.70–1.37) | 0.9 | 1.12 (0.77–1.65) | 0.6 |
| Type of care | ||||
| ICU | 0.63 (0.41–0.96) | 0.03 | 0.61 (0.39–0.94) | 0.03 |
| Clinical variables | ||||
| Diabetes | 1.70 (1.26–2.30) | 0.001 | 1.80 (1.28–2.54) | 0.001 |
| Systemic arterial hypertension | 1.61 (1.19–2.19) | 0.002 | 1.40 (0.99–1.99) | 0.06 |
| Obesity | 2.01 (1.35–2.99) | 0.001 | 2.69 (1.69–4.29) | <0.0001 |
| Heart disease | 3.41 (1.28–9.07) | 0.01 | 4.35 (1.29–14.64) | 0.02 |
| Lung disease | 1.36 (0.71–2.62) | 0.4 | 1.39 (0.68–2.87) | 0.4 |
| Cancer | 9.56 (2.02–45.35) | 0.004 | 15.27 (1.87–124.96) | 0.01 |
| Liver disease | 3.51 (0.58–21.15) | 0.2 | 2.12 (0.29–15.17) | 0.5 |
| Chronic kidney disease | 1.39 (0.69–2.81) | 0.4 | 1.43 (0.63–3.24) | 0.4 |
| Baseline SpO2/FIO2 | ||||
| <100 | 5.69 (3.48–9.31) | <0.0001 | 7.44 (4.18–13.24) | <0.0001 |
| 100–199 | 3.69 (2.57–5.29) | <0.0001 | 4.26 (2.86–6.33) | <0.0001 |
| ≥200 | Reference | Reference | ||
| Pharmacological treatments | ||||
| Hydroxychloroquine | 1.08 (0.78–1.49) | 0.7 | 1.13 (0.79–1.61) | 0.5 |
| Chloroquine | 0.81 (0.52–1.26) | 0.3 | 0.77 (0.48–1.25) | 0.3 |
| Azithromycin | 1.05 (0.76–1.43) | 0.8 | 0.94 (0.65–1.35) | 0.7 |
| Ceftriaxone | 0.82 (0.61–1.11) | 0.2 | 0.72 (0.51–1.02) | 0.07 |
| Lopinavir/ritonavir | 0.45 (0.25–0.83) | 0.01 | 0.51 (0.28–0.95) | 0.03 |
| Enoxaparin | 0.84 (0.62–1.15) | 0.3 | 0.88 (0.61–1.29) | 0.5 |
| Tocilizumab | 0.53 (0.25–1.12) | 0.09 | 0.58 (0.27–1.23) | 0.2 |
| Oseltamivir | 0.79 (0.52–1.21) | 0.3 | 0.82 (0.52–1.29) | 0.4 |
| Steroid (systemic) | 0.53 (0.35–0.81) | 0.004 | 0.47 (0.30–0.74) | 0.001 |
| Ivermectin | 0.89 (0.49–1.64) | 0.7 | 1.03 (0.55–1.91) | 0.9 |
| Supplemental oxygen delivery device | ||||
| Low-flow nasal cannula | 0.27 (0.19–0.38) | <0.0001 | 0.28 (0.19–0.41) | <0.0001 |
| High-flow nasal cannula | 0.77 (0.46–1.29) | 0.3 | 0.77 (0.42–1.44) | 0.4 |
| Nonrebreather mask | 3.94 (2.88–5.39) | <0.0001 | 3.75 (2.63–5.35) | <0.0001 |
ICU: intensive care unit; SpO2: peripheral arterial oxygen saturation; FIO2: inspiratory oxygen fraction.