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. 2021 Oct 25;9:757584. doi: 10.3389/fchem.2021.757584

FIGURE 4.

FIGURE 4

(A) Contours of steric contribution: green contour favors steric or bulky group, yellow contour denotes disfavored region. (B) Contours of electrostatic contribution: blue contour indicates electropositive charge, red contour electronegative charge.