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. 2021 Nov 8;18:262. doi: 10.1186/s12974-021-02302-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Comparison analysis of canonical pathways across ages using IPA. DEGs found in Tpp1^−/− vs control mouse cerebellum (Cb) and fore- and mid-brain (F/M) regions at 2–4 months were used in the analysis. Thirty top z-scores (A) and – log of Benjamini–Hochberg corrected p-value (B) are represented as a heatmap. Orange and blue colored z-scores represent activation and suppression, respectively. Dots indicate activation scores below 1.64 for A and corrected p > 0.05 for B