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. 2021 Nov 8;18:262. doi: 10.1186/s12974-021-02302-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Increase in choroid plexus gene expression in Tpp1^−/− brains. A Relative transcript expression of 5 genes upregulated in Tpp1^−/− choroid plexus were quantified by qPCR in independent F/M RNA extractions, performed in triplicate. Relative normalized expression values were determined from the ΔΔCt for the indicated target genes relative to Ppia (peptidylprolyl isomerase A) expression in control brains (wt). *p < 0.001; B Expression pattern of Lipopolysaccharide binding protein and Klotho (blue staining) in the lateral and 4th ventricle of Tpp1^−/− and control choroid plexus detected by mRNA in situ hybridization