Fig. 1.

miR-378a-3p expression is downregulated in HCC patients and correlated with HCC angiogenesis. A, B The mRNA expression of miR-378a in HCC and paired normal tissues was analyzed based on the TCGA and GEO databases. C, D Two chains of miR-378a were detected in 10 matched paired normal tissues and HCC tissues by qRT-PCR. E-G Relative miR-378a-3p mRNA expressions was measured in GEO datasets and in 108 pairs of specimens. H Tumor sections were stained with anti-CD34 for IHC assays and miR-378a-3p for FISH assays. I The correlation line between miR-378a-3p and MVD was analyzed by linear regression analysis. J, K OS and DFS were analyzed in HCC patients with high or low expression of miR-378a-3p by the Kaplan–Meier method. *P < 0.05; **P < 0.01; ***P < 0.001